Gomaa, A., Abdel - Mageed, W., Talaat, R., Neamatallah, M., El-Bendary, M. (2018). Molecular Biological Studies on Immune Responses Enhancement against HCV, the Role of Toll like Receptor. Journal of Agricultural Chemistry and Biotechnology, 9(1), 27-30. doi: 10.21608/jacb.2018.35154
Asmaa Gomaa; wael Abdel - Mageed; Roba Talaat; mostafa Neamatallah; mahmoud El-Bendary. "Molecular Biological Studies on Immune Responses Enhancement against HCV, the Role of Toll like Receptor". Journal of Agricultural Chemistry and Biotechnology, 9, 1, 2018, 27-30. doi: 10.21608/jacb.2018.35154
Gomaa, A., Abdel - Mageed, W., Talaat, R., Neamatallah, M., El-Bendary, M. (2018). 'Molecular Biological Studies on Immune Responses Enhancement against HCV, the Role of Toll like Receptor', Journal of Agricultural Chemistry and Biotechnology, 9(1), pp. 27-30. doi: 10.21608/jacb.2018.35154
Gomaa, A., Abdel - Mageed, W., Talaat, R., Neamatallah, M., El-Bendary, M. Molecular Biological Studies on Immune Responses Enhancement against HCV, the Role of Toll like Receptor. Journal of Agricultural Chemistry and Biotechnology, 2018; 9(1): 27-30. doi: 10.21608/jacb.2018.35154
Molecular Biological Studies on Immune Responses Enhancement against HCV, the Role of Toll like Receptor
2Genetic Engineering and Biotechnology Research Institute, Sadat University.
3Faculty of Medicine Mansoura University
Abstract
Epidemic disease with hepatitis C virus (HCV) was raised by scanty immune restraint. Empirical facts propose that low activation of TLRs 2-4 sensors participates to epidemic disease. We predestined the allocation of Single nucleotide Polymorphism (SNPs) in the TLR2 Arg677Trp in epidemic HCV disease and minus HCV sets. This research purposes to discuss the modulation of genetic ethnic polymorphisms of TLR2 gene in the epidemic HCV disease Egyptian positive HCV. TLR2 Arg677Trp rs121917864 (C/T) were genotyped in 549 positive HCV and 519 negative HCV sets. The combination analysis proved that the having of rare allele T of TLR2 Arg677Trp could have a low significant risk for epidemic HCV disease (OR= 1.5206 95%CI 1.1521 to 2.0069) and P = 0.0031.
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