Erian, N., Hamed, H., El-Khateeb, A., Farid, M. (2015). EFFECT OF CRUDE METHANOLIC EXTRACTS OF SOME MEDICINAL PLANT FLOWERS ON SOLID EHRLICH TUMOR IN MICE.. Journal of Agricultural Chemistry and Biotechnology, 6(11), 559-578. doi: 10.21608/jacb.2015.48462
N. S. Erian; H. B. Hamed; A. Y. El-Khateeb; M. Farid. "EFFECT OF CRUDE METHANOLIC EXTRACTS OF SOME MEDICINAL PLANT FLOWERS ON SOLID EHRLICH TUMOR IN MICE.". Journal of Agricultural Chemistry and Biotechnology, 6, 11, 2015, 559-578. doi: 10.21608/jacb.2015.48462
Erian, N., Hamed, H., El-Khateeb, A., Farid, M. (2015). 'EFFECT OF CRUDE METHANOLIC EXTRACTS OF SOME MEDICINAL PLANT FLOWERS ON SOLID EHRLICH TUMOR IN MICE.', Journal of Agricultural Chemistry and Biotechnology, 6(11), pp. 559-578. doi: 10.21608/jacb.2015.48462
Erian, N., Hamed, H., El-Khateeb, A., Farid, M. EFFECT OF CRUDE METHANOLIC EXTRACTS OF SOME MEDICINAL PLANT FLOWERS ON SOLID EHRLICH TUMOR IN MICE.. Journal of Agricultural Chemistry and Biotechnology, 2015; 6(11): 559-578. doi: 10.21608/jacb.2015.48462
EFFECT OF CRUDE METHANOLIC EXTRACTS OF SOME MEDICINAL PLANT FLOWERS ON SOLID EHRLICH TUMOR IN MICE.
Dept. of Agric. Chemistry, Faculty of Agriculture, Mansoura University, Egypt.
Abstract
Crude methanolic extracts of Cynara Cardunculus, Achillea millefolium, Calendula officinalis, and Matricaria chamomilla flowers belong to family Compositeaewere used in this work to study their efficiency to relief solid ehrlich tumor in mice. The more effective extract was with that of C. officinalis which decreased tumor size from 513.6 to 124.5mm at a dose of 200mg/kg body weightcomparing with doxorubicin which reduced tumor size to 98.2mm in concentration of 15mg/kg after 21 days, followed by M. chamomilla which showed the mean value of 157.1mm. While,the lowest values were with C. cardunculus and A. millefolium flowers extract which were 184.3 and 210.9 mm, respectively. Also, the more effective treatment weredoxorubicin in concentration of 15mg/kg and C. officinalis, followed by M. chamomilla, C. cardunculus and A. millefolium flowers methanolic extract for blood tests in tumor mice, e.g. antioxidant markers (MDA, TAC, SOD), liver functions (ALT, AST, Total proteins, Albumin and Globulins), kidney functions (Creatinine and Urea) lipid profile (triglycerides, total cholesterol, HDL, LDL and vLDL) haematological parameters (HB, RBCs, Plt and WBCs),comparing with control tumor mice at a dose of 200mg/kg body weight for 21 days.
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