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EL-Sawi, M., Amer, M., Muftah, S. (2017). Thymoquinone Protects Against Mercuric Chloride- Induced Hepatorenal Toxicity in Male Rats.. Journal of Agricultural Chemistry and Biotechnology, 8(1), 9-14. doi: 10.21608/jacb.2017.38412
M. EL-Sawi; M. Amer; Soad Muftah. "Thymoquinone Protects Against Mercuric Chloride- Induced Hepatorenal Toxicity in Male Rats.". Journal of Agricultural Chemistry and Biotechnology, 8, 1, 2017, 9-14. doi: 10.21608/jacb.2017.38412
EL-Sawi, M., Amer, M., Muftah, S. (2017). 'Thymoquinone Protects Against Mercuric Chloride- Induced Hepatorenal Toxicity in Male Rats.', Journal of Agricultural Chemistry and Biotechnology, 8(1), pp. 9-14. doi: 10.21608/jacb.2017.38412
EL-Sawi, M., Amer, M., Muftah, S. Thymoquinone Protects Against Mercuric Chloride- Induced Hepatorenal Toxicity in Male Rats.. Journal of Agricultural Chemistry and Biotechnology, 2017; 8(1): 9-14. doi: 10.21608/jacb.2017.38412

Thymoquinone Protects Against Mercuric Chloride- Induced Hepatorenal Toxicity in Male Rats.

Article 2, Volume 8, Issue 1, January 2017, Page 9-14  XML PDF (237.15 K)
Document Type: Original Article
DOI: 10.21608/jacb.2017.38412
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Authors
M. EL-Sawi; M. Amer; Soad Muftah
Zoology Department, Mansoura University, Mansoura- EGYPT
Abstract
The liver and kidney are imperative intentions for the toxicity of drugs, xenobiotics, thymoquinone (TQ) against mercuric chloride (HgCl2) induced hepatorenal toxicity in rats. HgCl2 at a dose of 0.02 mg/kg b w injected subcutaneously for 30 days, induced hepatotoxicity which confirmed in this study by increased activity (P ≤0.05) of liver function enzymes; CPK, whereas, serum total protein content and Na+-K+-ATPase activity were decreased significantly. Herein, HgCl2 induced also nephrotoxicity; as it induced noticeable signs of renal dysfunctions such as elevated levels (P < 0.05) of serum creatinine, blood urea nitrogen (BUN), uric acid as well as urine N-acetyl glucosaminidase (NAG) activity and total protein content. On the other hand there was a decline in the levels of urinary uric acid; creatinine and creatinine clearance. HgCl2 induced also oxidative stress in both liver and kidney tissues where reduced glutathione (GSH) content, superoxide dismutase (SOD) and catalase (CAT) activities decreased significantly; increased significantly. Additionally, TGF-β %, CD4% and CD8 % increased significantly in both liver and kidney tissues.  In conclusion: Treatment of TQ concomitantly with HgCl2 ameliorates effectively the significant changes of all the tested parameters.
Keywords
Thymoquinone; Mercuric chloride; Hepatorenal toxicity; Rats
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