Home Articles List Article Information
Journal of Agricultural Chemistry and Biotechnology
Journal Archive
Volume Volume 15 (2024)
Volume Volume 14 (2023)
Volume Volume 13 (2022)
Volume Volume 12 (2021)
Volume Volume 11 (2020)
Volume Volume 10 (2019)
Volume Volume 9 (2018)
Volume Volume 8 (2017)
Volume Volume 7 (2016)
Volume Volume 6 (2015)
Volume Volume 5 (2014)
Volume Volume 4 (2013)
Volume Volume 3 (2012)
Volume Volume 2 (2011)
Volume Volume 1 (2010)
Volume Volume 34 (2009)
Volume Volume 33 (2008)
Volume Volume 32 (2007)
Volume Volume 31 (2006)
Volume Volume 30 (2005)
Volume Volume 29 (2004)
Volume Volume 28 (2003)
Volume Volume 27 (2002)
Volume Volume 26 (2001)
Volume Volume 25 (2000)
EL-Sawi, M., Amer, M., Muftah, S. (2017). Thymoquinone Protects Against Mercuric Chloride- Induced Hepatorenal Toxicity in Male Rats.. Journal of Agricultural Chemistry and Biotechnology, 8(1), 9-14. doi: 10.21608/jacb.2017.38412
M. EL-Sawi; M. Amer; Soad Muftah. "Thymoquinone Protects Against Mercuric Chloride- Induced Hepatorenal Toxicity in Male Rats.". Journal of Agricultural Chemistry and Biotechnology, 8, 1, 2017, 9-14. doi: 10.21608/jacb.2017.38412
EL-Sawi, M., Amer, M., Muftah, S. (2017). 'Thymoquinone Protects Against Mercuric Chloride- Induced Hepatorenal Toxicity in Male Rats.', Journal of Agricultural Chemistry and Biotechnology, 8(1), pp. 9-14. doi: 10.21608/jacb.2017.38412
EL-Sawi, M., Amer, M., Muftah, S. Thymoquinone Protects Against Mercuric Chloride- Induced Hepatorenal Toxicity in Male Rats.. Journal of Agricultural Chemistry and Biotechnology, 2017; 8(1): 9-14. doi: 10.21608/jacb.2017.38412

Thymoquinone Protects Against Mercuric Chloride- Induced Hepatorenal Toxicity in Male Rats.

Article 2, Volume 8, Issue 1, January 2017, Page 9-14  XML PDF (237.15 K)
Document Type: Original Article
DOI: 10.21608/jacb.2017.38412
View on SCiNiTO View on SCiNiTO
Authors
M. EL-Sawi; M. Amer; Soad Muftah
Zoology Department, Mansoura University, Mansoura- EGYPT
Abstract
The liver and kidney are imperative intentions for the toxicity of drugs, xenobiotics, thymoquinone (TQ) against mercuric chloride (HgCl2) induced hepatorenal toxicity in rats. HgCl2 at a dose of 0.02 mg/kg b w injected subcutaneously for 30 days, induced hepatotoxicity which confirmed in this study by increased activity (P ≤0.05) of liver function enzymes; CPK, whereas, serum total protein content and Na+-K+-ATPase activity were decreased significantly. Herein, HgCl2 induced also nephrotoxicity; as it induced noticeable signs of renal dysfunctions such as elevated levels (P < 0.05) of serum creatinine, blood urea nitrogen (BUN), uric acid as well as urine N-acetyl glucosaminidase (NAG) activity and total protein content. On the other hand there was a decline in the levels of urinary uric acid; creatinine and creatinine clearance. HgCl2 induced also oxidative stress in both liver and kidney tissues where reduced glutathione (GSH) content, superoxide dismutase (SOD) and catalase (CAT) activities decreased significantly; increased significantly. Additionally, TGF-β %, CD4% and CD8 % increased significantly in both liver and kidney tissues.  In conclusion: Treatment of TQ concomitantly with HgCl2 ameliorates effectively the significant changes of all the tested parameters.
Keywords
Thymoquinone; Mercuric chloride; Hepatorenal toxicity; Rats
Statistics
Article View: 163
PDF Download: 449