Home Articles List Article Information
Journal of Agricultural Chemistry and Biotechnology
Journal Archive
Volume Volume 16 (2025)
Volume Volume 15 (2024)
Volume Volume 14 (2023)
Volume Volume 13 (2022)
Volume Volume 12 (2021)
Volume Volume 11 (2020)
Volume Volume 10 (2019)
Volume Volume 9 (2018)
Volume Volume 8 (2017)
Volume Volume 7 (2016)
Volume Volume 6 (2015)
Volume Volume 5 (2014)
Volume Volume 4 (2013)
Volume Volume 3 (2012)
Volume Volume 2 (2011)
Volume Volume 1 (2010)
Volume Volume 34 (2009)
Volume Volume 33 (2008)
Volume Volume 32 (2007)
Volume Volume 31 (2006)
Volume Volume 30 (2005)
Volume Volume 29 (2004)
Volume Volume 28 (2003)
Volume Volume 27 (2002)
Volume Volume 26 (2001)
Volume Volume 25 (2000)
Awad, A. (2017). Protective Effect of Nigella sativa Seeds Against Hepatotoxicity - Induced by Carbon Tetrachloride in Rats. Journal of Agricultural Chemistry and Biotechnology, 8(2), 57-62. doi: 10.21608/jacb.2017.38432
A. Awad. "Protective Effect of Nigella sativa Seeds Against Hepatotoxicity - Induced by Carbon Tetrachloride in Rats". Journal of Agricultural Chemistry and Biotechnology, 8, 2, 2017, 57-62. doi: 10.21608/jacb.2017.38432
Awad, A. (2017). 'Protective Effect of Nigella sativa Seeds Against Hepatotoxicity - Induced by Carbon Tetrachloride in Rats', Journal of Agricultural Chemistry and Biotechnology, 8(2), pp. 57-62. doi: 10.21608/jacb.2017.38432
Awad, A. Protective Effect of Nigella sativa Seeds Against Hepatotoxicity - Induced by Carbon Tetrachloride in Rats. Journal of Agricultural Chemistry and Biotechnology, 2017; 8(2): 57-62. doi: 10.21608/jacb.2017.38432

Protective Effect of Nigella sativa Seeds Against Hepatotoxicity - Induced by Carbon Tetrachloride in Rats

Article 5, Volume 8, Issue 2, February 2017, Page 57-62  XML PDF (888.7 K)
Document Type: Original Article
DOI: 10.21608/jacb.2017.38432
View on SCiNiTO View on SCiNiTO
Author
A. Awad
Agriculture Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt
Abstract
The present study aimed to examine the pre- and post-treatment effect of Nigella sativa water extract and crude oil against hepatotoxicity - induced by carbon tetrachloride in rats. The Nigella sativa extract or crude oil was screened for estimating their total phenolic contents and free radical scavenging activity. They have a high antioxidant activity due to phenolic compounds. Protective role of the Nigella sativa water extract and crude oil against carbon tetrachloride -induced alternation in blood biochemical and liver was evaluated. The examined extracts were administered 28 days before and 28 days after concomitantly with carbon tetrachloride for water extract and crude oil. Blood samples were determination of serum aminotransferases activity (ALT and AST), total protein (TP) albumin (Alb), urea, creatinine, and the activities of antioxidants such as glutathione-S-transferease (GST), superoxide dismutase (SOD),catalase (CAT) and malonialdehyde (MDA) content. The results detected that the  intraperitoneal injection of carbon tetrachloride motivate the increase in ALT and AST activity also urea, creatinine and liver MDA, meanwhile a high decrease in the levels of total protein, albumin and liver GST, SOD, CAT were obtained. The results revealed that Nigella sativa water extract or crude oil had a protective effect against the carbon tetrachloride -induced.
Keywords
Nigella Sativa; crude oil extract; antioxidant markers; Hepatic Injury
Statistics
Article View: 166
PDF Download: 439